An Ancient Portal to Proteolysis
نویسندگان
چکیده
منابع مشابه
Site-2 protease regulated intramembrane proteolysis: sequence homologs suggest an ancient signaling cascade.
Site-2 proteases (S2Ps) form a large family of membrane-embedded metalloproteases that participate in cellular signaling pathways through sequential cleavage of membrane-tethered substrates. Using sequence similarity searches, we extend the S2P family to include remote homologs that help define a conserved structural core consisting of three predicted transmembrane helices with traditional meta...
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ژورنال
عنوان ژورنال: Science
سال: 2012
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1227301